在第57位实验核磁共振会议,布鲁克(Bruker)展示了几种创新的药物发现,药物开发和工艺控制解决方案,用于化学和制药行业中的小分子NMR表征。
Assurenmr与手工艺:现在可以完全降低幅度频率表(工艺)和生物制剂分析工具Assurenmr™2.1揭示了复杂材料(例如生物流体,培养基和生物学)的小结构和组成变化,对产品质量控制很重要。亚博网站下载Craft基于目标指纹提供关键代谢物的匹配和量化。通过合并大型公共代谢组数据库(HMDB)和药物库数据库的能力,代谢物鉴定可以增强,分别含有超过900 nMR的代谢物和药物化合物。
这些功能代表了Assurenmr软件包的主要增强功能,用于详细的生物流体系统分析。
Anthony Ribeiro-杜克大学医学中心
实验选择器:The latest release of TopSpin® software, TS3.5pl6, features a new, user-friendly GUI which provides easy access to vast experiment libraries including standard Bruker pulse sequences and user generated experiment libraries for both industrial and academic users. The GUI enables users to build and organize their own customized experiment libraries via simple drag and drop, provides multiple options for experiment setup and optimization, enables script based parameter adjustment, and makes the setup of sophisticated experiments simple and efficient.
Free TopSpin Processing:为了为学生,讲师和研究人员提供无限访问的离线NMR处理工具的无限访问,Bruker正在使他们的市场领先的NMR处理软件Topspin免费为所有学术用户提供。除了Bruker NMR数据外,该软件还能够处理Agilent,Varian和Jeol Systems获得的数据,并且可以读取以JCAMP格式提供的数据。有关Topspin软件的下载,请单击这里。
SmartDrivenMr:布鲁克(Bruker)通过其“智能NMR光谱仪计划”为NMR解决方案设定新标准。该项目的目的是将自动,智能的决策纳入光谱仪。SmartDrivenMR - 朝这个方向发展的另一个步骤 - 决定一套优化的NMR实验集,该实验在用户定义的时间范围内提供最佳的信息,以解决给定的光谱问题。SmartDrivenMR仅通过自动运行这些实验来节省光谱仪的时间,这些实验添加了最大值来解决给定问题。SmartDrivenMR无缝集成到行业标准的常规NMR获取软件ICONNMR中,以提供结构一致性分析的解决方案,这在大多数NMR服务实验室中很常见。
LAB2NMR:This adaption of the automation and scheduling system lab2labTM (http://ttplabtech.com) allows NMR samples in modern, larger analytical service organizations to be transported to the instrument via the lab2lab pipe system. Samples are submitted for analysis directly from the chemist’s bench in standard vials. The lab2lab system transports these vials to remote analytical NMR instrument via a pipe system. Once at the instrument, lab2NMR accepts the sample, prepares it for NMR measurement and schedules the experiment. This system improves the efficiency and the load-factor, thus enhancing NMR productivity.
With the latest addition of Lab2NMR, our well established lab2lab system for rapid, flexible and hassle-free open access routine analytics became even more productive.
Now, chemists can send off samples for NMR analysis as easily and with the same interface as they are used to from LC-MS. The resulting spectra are in their inbox much faster than previously, when the chemist had to find the closest available open access system.
Haraldschröder博士 - 诺华巴塞尔
新的自动化工具:新的Samplecase加热专为聚合物研究的工作而设计。它能够在最多125°C的温度下保持多达24个样品,使聚合物保持液体并准备进行测量。布鲁克还宣布了SampleJet AutoSampler的下一代冷却架。这个新的模块允许对五个样品架中的每一个进行单独的冷却和温度调节。借助其他96个无旋转器开放访问样品位置,样品jet是代谢组学和生物筛查应用的最佳选择。
Bruker Fusion-SV 1.1:Bruker Fusion-SV 1.1在药物和化学研究中针对小分子的自动结构验证解决方案的新版本整合了高分辨率,准确的质量质谱质谱法,用于使用NMR光谱进行自动化化学公式的生成。现在,更新的Bruker Fusion-SV 1.1解决方案现在包括其他2D NMR方法,以提高对快速自动结构验证的信心。Bruker Fusion-SV 1.1专为制药,化学工业或学术界的药用和合成化学家的工作流程而设计,指导化学家以最少的相互作用,而无需专业知识。
Insightmr:Designed for the optimization of chemical reactions under process conditions, the new InsightMR™ solution uses on-line NMR monitoring to enhance process understanding. InsightMR has a new flow unit with temperature-controlled transfer lines to enable fast and continuous transfer of reaction mixtures from a vessel to the spectrometer. InsightMR software features a user-friendly interface to allow both expert and non-expert NMR users to set up experiments in deuterated and non-deuterated solvents and optimize acquisition parameters on-the-fly, based on real-time kinetic data.
傅立叶300高清:2010年,布鲁克(Bruker)推出了成功的入门级NMR系统,即傅立叶300。根据积极的客户响应,我们现在推出了改进的版本,即傅立叶300 HD。Fourier 300 HD源自我们著名的Avance III HD电子产品,为注册意识客户提供了一个针对质子和碳操作的入门级,两通道系统。该系统的规格与我们的Avance系列相同,并且由Topspin软件运行。Fourier 300 HD凭借其较小的占地面积和免费提供的Topspin处理软件(仅限于学术用户),是教育和较小常规实验室的绝佳系统。
除了开发高场磁铁(例如我们的新Aeon 1 GHz磁铁)以及新的,高度敏感的X-Nucleus Direct Dickecty Croprobes外,我们还将研发集中在研发上,这些工具可以通过提高其生产率或扩大其范围来使客户成功的工具NMR应用程序。
In addition to introductions for sample handling and data analysis, we started the Intelligent NMR Spectrometer Initiative, a multi-year program to enhance productivity and ease-of-use of our spectrometers. SmartDriveNMR and lab2NMR are just two of the early results of this program.
Werner E. Maas博士 - Bruker Biospin MRS部门总裁