将CVD用于化学涂料的好处

An interview with Dr. Jesse Bischof, Researcher at SilcoTek, about the process involved with creating new chemical coatings for industrial applications and the benefits of using CVD for chemical coatings。

CVD涂料与传统涂料有何不同？主要区别是什么？

Traditional coatings are mostly line of sight in nature, meaning that only the surface facing the source of the coating will receive that coating. CVD coatings have the ability to coat in a non-line of sight fashion. Anywhere the precursor gas can reach, the part will be coated. This allows us to reach the internal surfaces of frits. Traditional coatings would only be able to coat the externals of the frit surface, where we can coat through the entirety of the frit.

What is the advantage to choosing CVD coatings over traditional coatings?

在HPLC世界中，涂料是一个相对较新的解决方案。在我们提供产品之前，该行业从不锈钢转移到了一个名为“窥视”的硬塑料，以进行任何金属敏感分析。PEEK带来了自己的一组问题，包括劣质板制造（与不锈钢相比），圆柱体宽度变化，并且不如不锈钢强，因此UHPLC分析不是一种选择。其他人则尝试了窥视和玻璃衬里的钢体，但这并不能解决板块中的问题，而是在柱子的上下管道。其他一些涂层选择，例如特氟龙涂料或溶胶 - 凝胶涂料，尤其是在弗里特和分层问题中。CVD涂层共价结合到底物，因此不会发生分层。

为什么惰性流道关键？它对您的结果有什么影响？

液相色谱的心脏正在利用分析物可能与色谱柱包装材料具有的各种化学和物理相互作用。分析物可能沿流动路径的任何其他相互作用都会对分离有害。不锈钢是首选的材料，当然有大量分析物要么不相互作用，要么仅与钢流道相互作用，但是我们的涂料可以通过使从注射到检测的所有物质使一切互动来消除这种相互作用的可能性。

当使用不惰性的流道对高度活性的分子进行分析时，它们可能会落后或卡在流道中。这将导致您的分析发生两个变化。首先，在对流路径材料有轻微到中等吸引力的情况下，您可能会看到严重的峰值尾巴。其次，如果分析物高度吸引流动路径或较小的浓度，您根本看不到峰。可以通过使用Dursan技术涂上流道来消除这两个问题。

什么好处使Dursan Silcotek的HPLC涂层首选解决方案？

Most of our CVD coatings will create a barrier between the metal substrate and the flow path, but Dursan is our HPLC coating of choice due to two main reasons: Bio-inertness and pH stability. Protein analysis using HPLC is growing rapidly. Many pharmaceutical companies have moved away from small molecule drug development and are working toward protein based drugs called “biologics”. In a collaborative investigation with Abbott Laboratories, we found that Dursan is an excellent anti-fouling coating for proteins1。The other reason is that some analyses utilize high pH conditions. Most of our coatings are resistant to pH less than 7, but Dursan is the only coating that is usable in the full pH range (0-14).

Dursan耐腐蚀是否能够承受恶劣的环境和恶劣的测试条件？为什么这对应用程序很重要？

Dursan is very corrosion resistant. We have yet to see a typical HPLC additive that would negatively impact Dursan, where as stainless steel can have issues with halides, certain buffers, and salts. Alternative materials such as titanium can experience issues with pure organics such as methanol or acetonitrile. Any time a system experiences corrosion, there are unwanted metal ions entering the flow path and possibly causing analysis issues. Often times when iron or titanium ions enter the column, they can bind to active sites on the silica irreversibly and can essentially kill the column. Additionally, since HPLC analysis does occur at high pressures, any corrosion of the instrument can be detrimental.

Can you tell us about some case studies where Dursan was applied? What benefits did the industry see?

A local machine shop that specializes in producing HPLC columns was experiencing a demand from their customers for a bio-inert column for various types of analyses. Unfortunately, they were experiencing issues with sourcing quality frits for their columns. Utilizing Dursan coated stainless steel, they can sell a bio-inert column without the need for inferior frits that are much more expensive. They are very happy to know that they can now provide a bio-inert column that has the robustness of stainless steel and the inertness of PEEK at a fraction of the cost of titanium. They appreciated the fact that they did not have to change anything about the way they machine their columns. Dursan is a perfect solution for ready-made stainless steel products.

What is in store for the future of Dursan?

Dursan在HPLC市场中的未来将集中在定制上。目前，我们有许多潜在的客户在其HPLC应用程序中评估Dursan，并且我们已经在涂层上收到了许多对各种表面功能化的要求，就像您在HPLC列的包装材料上所获得的一样。此外，我们正在评估列和弗里特的寿命，以确保达尔桑能够在列的寿命中持续下去。

Where can our readers go to find out more?

We have a vast library of resources for our customers to choose from in our online学习中心。我们收集了大量的数据表，应用指南，网络研讨会，电子书，博客文章等等。

关于杰西·比索夫博士

杰西·比索夫（Jesse Bischof）博士的职业生涯开始了两年的高中化学课程，然后才去宾夕法尼亚州立大学的研究生院，在那里他获得了博士学位。在化学中。杰西（Jesse）于2016年获得学位后，开始担任Silcotek研究与发展部的研究员。杰西（Jesse）的专业知识帮助了医学和分析市场的客户，以提高零件性能，物质表征和仪器。目前，杰西的研究重点是开发和优化生物恩特涂料以及抗雾化涂料。