To successfully develop new active pharmaceutical ingredients and gain approval, Researchers need the precise 3D structure of the substances. If they comprise of individual crystals, the spatial structure can be established using X-ray structural analysis. In many cases, however, Researchers have access only to powder, blends of crystalline grains between 10–500 nm in size.
Electron Nanocrystallography
瑞士纳米科学学院最近资助了P亚博老虎机网登录aul Scherrer Institute（PSI）的TimGrüne博士领导的A3EDPI项目。该项目是由PSI和Uni Basel（C-CINA）的学术团体进行的多学科合作，以及Dectris和Hoffman-La Roche等工业合作伙伴。
dectrisis the global leader in Hybrid Photon Counting (HPC) detectors, and it was already associated in an earlier SNI-PSI NanoArgovia collaboration to substantiate the suitability of HPC detectors for micro Electron Diffraction studies.
Please click here if you would like more information on the product in this article or a quote
Since the result was very promising, the A3EDPI project is a follow-up and the central goal is to examine whether electron nanocrystallography can be used efficiently to shed light on the spatial structure of the various molecules.
As we are expanding into the Electron Microscopy (EM) market, a successful collaboration is a very important step in setting the basis for success, especially since Pharma companies are looking closer to the potential of EM to solve the structure of small medical compounds.
Dr. Clemens Schulze-Briese,首席科学官dectris
在EM中，将样品放置在高能电子束下。电子具有波特性；根据原子的组织方式，为每个分子生成非常详细的衍射模式，该模式为其原子结构提供了理解。使用一些模型物质的初步实验已经返回了质量非凡的数据。该团队目前正在研究是否电子纳米结晶学可以进一步发展为制药和化学领域的吸引力标准，以及是否可以满足工业应用的绩效和质量要求。
.jpg)
Figure 1.Diffraction pattern of a 400 nm crystal of the antibiotic Epicorazine A. The data quality is so high that all hydrogen atoms apart from one (yellow atom) have been allocated automatically and correctly – something that cannot be taken for granted even in X-ray structures with much larger crystals. (Image: Tim Grüne, PSI). Image credit: Dectris Ltd.
此信息已从Dectris Ltd提供的材料中采购，审查和调整。亚博网站下载
For more information on this source, please visitDectris Ltd.